"Biodefense in the Age of Synthetic Biology": Warfare Applications Of Attacking Populations Through Their Microbiome And Immune System

Ana Maria Mihalcea, MD, PhD - Feb 04, 2024 ∙ Paid ∙ Source

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Biodefense in the Age of Synthetic Biology

I would like to draw attention to this Department of Defense sponsored paper explaining how synthetic biology can be used for warfare purposes. Note that one stealth attack of humans is to attack or modify the gut microbiome, which affects the immune system and mental health. Interestingly, the Covid 19 bioweapon injections and the original Covid weapon did just that, modify the microbiome. I have been arguing that polymer plastics are involved in the toxicity of the C19 bioweapons that self spread. Clinically, I have seen many people complain about gastrointestinal problems, like diarrhea, nausea, bloating, cramping, lack of appetite, extreme fatigue and brainfog after eating food, especially meat. I had shown that meat is a source of extreme contamination.

Contaminated Food Supply Contributing Cause To Live Blood Analysis Findings In Unvaccinated? Darkfield Blood Analysis On Grocery Meat Products

The specific dual use application, meaning military and civilian is what we need to explore and be informed about.

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Synthetic biology collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms. While the goals of synthetic biology are beneficial, these capabilities also could be used to cause harm. This report assesses the security concerns raised by synthetic biology in order to inform efforts to mitigate potential threats. The age of synthetic biology has brought with it opportunities to transform approaches to treating disease, manufacturing chemicals, producing fuels, remediating contaminants, and numerous other applications with benefits to humankind.

Some synthetic biology capabilities, however, have dual use potential — that is, they can be misdirected to cause harm to humans, animals, plants, and the environment. Synthetic biology makes possible new types of weapons and adversaries that the United States’ approach to biodefense was not originally designed to counter.

Making informed decisions about whether and how to mitigate potential malicious uses of synthetic biology requires a realistic assessment of security concerns. To that end, the U.S. Department of Defense, working with other agencies involved in biodefense, asked the National Academies of Sciences, Engineering, and Medicine to develop a framework to guide an assessment of the security concerns related to advances in synthetic biology, to assess the levels of concern warranted for such advances, and to identify options that could help mitigate those concerns.

Framework For Assessing Synthetic Biology (Weapons) Capabilities

Synthetic biology concepts, approaches, and tools do not, in and of themselves, pose inherent harm. Rather, concerns derive from the specific applications or capabilities synthetic biology might enable. The report outlines a framework for assessing concerns related to synthetic biology-enabled capabilities (Figure 1). In its deliberations, the committee used this framework along with its members’ subject matter expertise to analyze specific capabilities in terms of each of four factors: usability of the technology, usability as a weapon, requirements of actors, and potential for mitigation. In addition

Of the potential capabilities assessed, three currently warrant the most concern: r e-creating known pathogenic viruses, making existing bacteria more dangerous, and making harmful biochemicals via in situ synthesis. The first two capabilities are of high concern due to usability of the technology. The third capability, which involves using microbes to produce harmful biochemicals in humans, is of high concern because its novelty challenges potential existing mitigation options.

Here are the ways that synthetic biology can be used in a weaponized way. What is described is also known as Gain of function research.

Growing number of high-security pathogen labs around world raises concerns New analysis tallies more than 100 labs studying deadly human and animal viruses

Synthetic biology is the fusion of organic material with synthetic material or technology. COVID 19 was a synthetic bioweapon. The spike sequence was encoded to manufacture hydrogel proteins that would create amyloid structures.

Amyloid and Hydrogel Formation of a Peptide Sequence from a Coronavirus Spike Protein Amyloid and Hydrogel Formation of a Peptide Sequence from a Coronavirus Spike Protein

The other synthetic biology aspect was the introduction of modified mRNA with pseudouridine - that can trick the immune system.

Harnessing synthetic biology for advancing RNA therapeutics and vaccine design

The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines

I would also argue, that a normal organism does not produce microchips and self assembly filaments, Quantum Dots and micro robots. Hence all of what we found is weaponized synthetic biology.

Here is further discussion of the topic and how it works. Note that plasmids and DNA, which both have been found in the C19 bioweapons, are noted as an effective means to attack humans with synthetic bioweapons.

Assessment of Concerns Related to Bioweapons that Alter the Human Host

Human health is highly dependent upon the human microbiome—the microorganisms that live on and within us, especially those associated with the gut, oral cavity, nasopharyngeal space, and skin. These populations of microbes are likely far easier to manipulate than the human host itself, making the microbiome a potentially accessible vector for attack. The human microbiome is the focus of a great deal of academic and commercial research, and microbiome manipulation is an area that is rapidly developing, as also discussed in Chapter 5 . Several possible ways the microbiome could be manipulated to cause harm were considered; these possibilities were analyzed, in aggregate, to determine the level of concern warranted.

Delivery of harmful cargo via the microbiome. As discussed in Chapter 5 , the engineering of microorganisms to produce hazardous chemicals or biochemicals (including toxins) poses a medium to high level of concern and the potential for making chemicals or biochemicals in situ via the microbiome warrants a high level of concern. The microbiome could be used as a vector for other types of harmful cargoes, as well. For example, microbes could be modified to produce functional small RNAs (e.g., microRNAs [miRNAs]) that could be transferred to the host via the gut or skin microbiome ¹ to cause a variety of health impacts. ² Microbes also could potentially be engineered to horizontally transfer a genetic cargo to the native microbiome to, for example, cause a host's own well-established microbes to produce a harmful biochemical. In such a scenario the harmful agent would be manufactured by organisms in the established microbiome, so the engineered microbe would need to infiltrate and persist within the microbiome only long enough to transfer its cargo to a sufficient number of native microbes. Thus, this approach would circumvent the challenges associated with establishing engineered microbes in otherwise occupied niches. There are many known instances of natural horizontal transfer events that result in the production of toxins ( Kaper et al., 2004 ; Strauch et al., 2008 ; Khalil et al., 2016 ). It may be possible to harm a population by enhancing the spread of vectors or phage (viruses targeting bacteria [ Krishnamurthy et al., 2016 ]) carrying such genetic cargoes. Synthetic biology methods could advance such a capability, for example, through the engineering of toxin:antitoxin couples that would help ensure retention of plasmids. It is also conceivable that microbes could one day be engineered to horizontally transfer genes directly to human cells.

Here is what scientists have found in the C19 bioweapon vials:

Interview with Kevin McKernan, scientist who discovered DNA contamination in mRNA shots

Sequencing of bivalent Moderna and Pfizer mRNA vaccines reveals nanogram to microgram quantities of expression vector dsDNA per dose

Please note the weaponizaton of pathogens is discussed and the libraries that scientists can use to engineer more effective weapons:

Use of the microbiome to increase the impact of an attack. The microbiome can also potentially be exploited to design a more effective bioweapon or increase the impact of an attack. Knowledge of the human microbiome could be used to modify pathogens or their delivery mechanisms to allow more efficient propagation within or between populations, for example, by taking advantage of the frequent exchange of bacteria between humans and animals. In particular, domestic animals could be used as carriers for engineered agents transmitted via the microbiome. For example, engineered dog or cat microbiomes could be established via adulterated feedstocks or via purposeful contamination of populations in animal shelters or pet stores and then subsequently transmitted to humans. Natural transfers resulting from animal-human contact, such as the transfer of the parasite Toxoplasma gondii from cats to humans and the transfer of Campylobacter from dogs to humans, illustrate the feasibility of this approach ( Jochem, 2017 ). Similarly, research into the role of the microbiome in pathogenesis could provide a roadmap as to how to generate improved pathogens that are better supported by their microbial peers. Studies involving wide-ranging transposon- or CRISPR-based deletion libraries of pathogens ( Barquist et al., 2013 ) have provided many insights into pathogenesis that might have dual-use implications, and such libraries could prove useful in identifying which genes productively or specifically interact with endogenous flora to better establish a pathogen.

In addition to using the microbiome to spread toxins and pathogens, manipulating the microbiome might also prove to be a useful adjunct for other biological threats. Recent research shows, for example, that eukaryotic viruses utilize bacteria to improve their chances of infection ( Kuss et al., 2011 ). It is also conceivable that an actor could introduce an initial agent into a population in order to trigger widespread treatment with broad-spectrum antibiotics and then take advantage of the treated population's “clean slate” to introduce or expand an engineered organism via the (now disrupted) microbiome. An actor taking this two-step approach could even incorporate antibiotic or antiviral resistance elements into the initial attack.

We now know that we are being attacked from every angle, contaminated air via geoengineering warfare, contaminated food and water. It talks about contaminating supplements, which we have found as well. What we are living through is described by the DOD as a viable way for warfare against populations:

Usability as a Weapon

There are many known routes for the introduction of bacteria into populations; the gut, mouth, nasal, or skin microbiomes could potentially be infiltrated through ingestion, dermal, or other exposure routes via a wide variety of avenues, from contaminated food or water to airborne sprays. For the warfighter, the uniformity of the food supply chain may make food of particular concern as a vector for attack; additionally, products such as probiotics and herbal supplements, routinely used by many warfighters ( Hughes et al., 2010 ; Daigle et al., 2015 ) could be exploited. It also may be possible to engineer a bioweapon to target populations with a specific microbiome profile; any adversary that begins to better parse, store, and analyze the data that are increasingly being collected about human microbiomes will also be in a better position for probabilistic targeting of microbiome threats (see also Chapter 7 , Targeting). However, the predictability of the results for manipulation of the microbiome will be low and, unlike conventional pathogens, the opportunities for dissemination via human-to-human transmission are reduced. On balance, the availability of routes to introduce bacteria tempered by the lack of predictability leads to an overall level of medium concern for this factor.

Here are scientific articles that discuss Covid patients had significant abnormalities of their gut microbiome:

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

The C19 bioweapons lead to deaths in the elderly by this exact mechanism.

Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination

mRNA vaccine against Covid-19 has been designed to trigger an immune response to one of the surface spike proteins of the virus that enables its entry into human cells. The vaccine induces local inflammatory reactions. Recently, in Norway, 23 fragile vaccinated elders died due to common adverse reactions such as, fever, nausea and diarrhea. Since human mucosal tissues of the gut are involved in immune response to Covid virus, adverse reactions could be due to dysbiosis of the gut commensals that change with age and personalized nutrition.

The gut microbe composition of individuals with a high intake of protein and animal fat, like the western diet, is generally dominated by a Bacteroides driven enterotype, which is the largest phylum of the gut microbiome community. Some genera of Bacteroidetes stimulate macrophages and monocytes to secrete a complex array of pro-inflammatory cytokines such as IFNγ and TNFα, neurotoxins including surface lipopolysaccharides and toxic proteolytic peptides in the plasma. Secretion of these cytokines and toxins result in aberrant immune responses, involving elevated levels of circulating cytokines and immune-cell hyperactivation, thus contributing to abnormal inflammatory reactions due to cytokine storms.

Probiotics were able to prevent spread of illness:

Daily Lactobacillus Probiotic versus Placebo in COVID-19-Exposed Household Contacts (PROTECT-EHC): A Randomized Clinical Trial

Please note what they call microplastics is what I call polymers, self assembly nanotechnology. It is all the same thing, is highly toxic, can deliver a payload that can kill people as seen in the case of the elderly dying from diarrhea post C19 bioweapon injection. Synthetic biology, which the C19 shots are and the many different ways outside of shedding that can be used to attack the human - biological warfare can go through the gut.

Microplastics and the gut microbiome: How chronically exposed species may suffer from gut dysbiosis

Despite increasing awareness, one potentially major consequence of chronic exposure to microplastics has been largely neglected: the impact of the disruption of the symbiosis between host and the natural community and abundance pattern of the gut microbiota. This so-called dysbiosis might be caused by the consumption of microplastics, associated mechanical disruption within the gastrointestinal tract, the ingestion of foreign and potentially pathogenic bacteria, as well as chemicals, which make-up or adhere to microplastics. Dysbiosis may interfere with the host immune system and trigger the onset of (chronic) diseases, promote pathogenic infections, and alter the gene capacity and expression of gut microbiota.

Microplastics are everywhere. They have been shown to cause fatal malnutrition, act as long-distance vectors for potential pathogens, harbor chemicals that can interfere with organismal biochemistry and hormone balance, and attract environmental chemicals that may be partially and temporarily hidden like a hoard of soldiers armed with different weapons inside a Trojan horse.

Summary:

I wanted to explain this, since I see so many people who have never before gut issues, associated with extreme fatigue and brain fog, as well as decreased immunity against infections. Yes, your gut can be a target of synthetic biological and technological warfare and it is even a pathway to genetically modify humans. Good probiotics can be a very important support tool. Dr Sabine Hazan, world expert on the research connecton between Covid 19 and the microbiome, did studies on sauerkraut and found it was very effective to restore the bifidobacterium that were being wiped out in the C19 vaccinated and post Covid. Clean food and water is important to lower the contamination of the body.

Related articles:

Study Shows How Microplastics Can Easily Climb The Food Chain

Microplastics - aka Nanotechnological Self Assembly Polymers - Are Everywhere - Poisoning Our Biosphere, Food Supply And Humans

Recent Consumer Report Reveals High Levels Of Plastics In All Food Categories - Is Poisoning Our Biosphere Via Geoengineering The REAL Cause?

Study Shows A Quarter Million Nanoparticle Polymers Per Liter In Water Bottles - Same Polymers Found As In Moderna Patent For Covid 19 Shots, Morgellons Filaments, Blood & Rubbery Clots

Global Healing Probiotics

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